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4.2 Remodeling the tumor microenvironment and reversing the immunosuppressive state 4.2.1 Systemic antitumor immune activation After oncolytic bacteria lyse tumor cells, they release damage-associated molecular patterns (DAMPs) such as calreticulin, ATP, and HMGB1, along with a large amount of tumor-specific antigens, forming an endogenous tumor vaccine
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