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Anti-inflammatory NF-κB Modulation MC1R and MC3R activation by melanocortin peptides has been shown to suppress NF-κB nuclear translocation and downregulate pro-inflammatory cytokine production (TNF-α, IL-6, IL-1β) in macrophage and keratinocyte models, suggesting a role in cutaneous inflammatory signaling research (Luger et al., Journal of Investigative Dermatology, 1997)

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Regulatory feedback mechanisms leading to an increase in the dietary absorption of LC, and/or de novo synthesis may take place to overcome the LC deficiency and reduce the loss by urinary excretion