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One frequently cited safety figure comes from acute toxicity studies in mice: the median lethal dose for GHK-Cu was calculated at roughly 320 mg/kg, extrapolated to human body weight, a wide margin relative to the microgram-to-milligram concentrations used in topical and research formulations

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The PI3K/AKT signaling pathway is closely related to the mechanisms of cell survival, cell metabolism, and apoptosis