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This may be how glutamate plays a role in migraine (and why MSG is a migraine trigger for some people).[ref] Related article : Migraine genes Role of glutamate in schizophrenia: Researchers have known for some time that glutamate plays a significant role in schizophrenia, but it’s not clear whether it is due to excess glutamate, dysfunction of the NMDA receptor, or dysregulation in specific brain regions