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Studies of another thiol-containing antioxidant N -acetylcysteine (NAC), at its intrinsic pH, showed that it destabilizes the biofilm matrix by chelating divalent cations (e.g., Ca 2+ and Mg 2+ ), inhibition of bacterial extracellular polysaccharide production, modulation of bacterial cell physiology and the impact on its metabolism (Olofsson et al., 2003

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Taken together, our results suggest that clofazimine conferred protection against SARS-CoV-2 challenge in the hamster model by reducing virus replication and associated inflammatory dysregulation in the host